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房晨婕

 

姓名:房晨婕

性别:女

职称:教授

招生院所:云顶5555yd

招生类型:博士、硕士

招生专业:药剂学

研究方向名称:纳米材料及其生物医药的应用基础研究

电子信箱:cjfang@ccmu.edu.cn

个人简介

2007年进入首都医科大学云顶5555yd工作。研究领域着重于分子材料、纳米材料的生物医学应用。在国际重要期刊发表多篇研究论文,其中3篇被选为封底文章,1篇被Chem. Rev.引用点评,1篇获New. J. Chem.年度hot papers提名。主持国家及北京市自然科学基金项目、北京市教委项目及留学回国人员项目。系列研究成果入选北京市自然科学基金“十二五”期间优秀成果。兼任国家基金委和北京市、天津市等多个省市基金委及海外基金项目评审专家。

 

教育经历

2001,南京大学,配位化学国家重点实验室,博士

 

工作经历

2007至今,首都医科大学云顶5555yd,副教授、教授

2004~2006,北京大学稀土材料化学及应用国家重点实验室,博士后

2002~2003,Nottingham University, K C Wong fellowship

2001-2002,Johann Wolfgang Goethe-Universität Frankfurt amMain,博士后

 

重要学术论文:

(1)Ailing Sun, Di Qian, ZhengWang, Yiliang Xu, Haihong Ye,* Chen-Jie Fang,* Chun-Hua Yan, Protective effect of lipoic acid modification on brain dysfunctions of mice induced by mesoporous silica nanoparticles, Chem. Eng. J. , 2021, DOI: 10.1016/j.cej.2021.128957.IF10.652

(2)Yuqian Jiang, Zheng Wang, Wei Duan, Lingyan Liu,* Mahan Si, Xiaoyuan Chen,* Chen-Jie Fang.* The critical size of gold nanoparticles for overcoming P-gp mediated multidrug resistance, Nanoscale , 2020, 12, 16451-16461. Back cover article. IF6.895

(3)Xiaomin Zhi, Yuqian Jiang, Linlin Xie, Yanbo Li, Chen-Jie Fang,* Gold nanorods functionalized with cathepsin B targeting peptide and doxorubicin for combinatorial therapy against multidrug resistance, ACS Appl. Bio Mater. , 2019, 2, 5697-5706.

(4)Linlin Xie, Xiaomin Zhi, Nao Xiao, Chen-Jie Fang,* Chun-Hua Yan, Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities, RSC Adv. , 2018, 8, 26517-26522.

(5)Rui-Hui Wang, Jie Bai, Jun Deng, Chen-Jie Fang,* Xiaoyuan Chen,* TAT-Modified gold nanoparticle carrier with enhanced anticancer activity and size effect on overcoming multidrug resistance, ACS Appl. Mater. Interfaces , 2017, 9(7), 5828-5837. IF8.758

(6)Jie Bai, Rui-Hui Wang, Yan Qiao, Aidong Wang, Chen-Jie Fang,* Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index, Drug Design, Development and Therapy , 2017, 11, 2227-2237.IF3.216

(7)Ming Zhou,# Linlin Xie#, Chen-Jie Fang,* Hua Yang, Yan-Jie Wang, Xiao-Yu Zhen, Chun-Hua Yan,* Yuji Wang, Ming Zhao,* Shiqi Peng,* Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification, RSC Adv. , 2016, 6, 2800-2809.

(8) Rui Guo, Le-Le Li, Wen-Hua Zhao, Yu-Xi Chen, Xiao-Zhu Wang, Chen-Jie Fang,* Wei Feng,Tian-Lan Zhang, Xiang Ma, Meng Lu, Shi-Qi Peng* and Chun-Hua Yan, The intracellular controlled release from bioresponsive mesoporous silica with folate as both targeting and capping agent, Nanoscale , 2012, 4, 3577–3583. Back cover article. IF6.895

(9)Wenjing Wang, Chenjie Fang*, Xiaozhu Wang, Yuxi Chen, Yaonan Wang, WeiFeng, Chunhua Yan, Ming Zhao* and Shiqi Peng*, Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy, Nanoscale , 2013, 5, 6249-6253. Back cover article. IF6.895

承担重要项目

21571133,介孔氧化硅引发的氧化应激及其神经化学,国家自然科学基金委,60万,2015.01-2019.12。

21171120,穿越血脑屏障、细胞内环境导放药物的多功纳米器件研究,国家自然科学基金委,55万, 2012.01-2015.12

KZ201710025024,硫辛酸在介孔氧化硅引起的氧化应激及神经毒性中的保护作用,北京市自然科学基金-北京市教委重点项目,50万,2015.01-2019.12

7132020,生物响应的氧化硅纳米载体在联合化疗中的应用基础研究,北京市自然科学基金委,14万,2013.01-2015.12

208207具有可控及定点释放性能的纳米运输器件研究,北京市自然科学基金委,10万,2008.01-2010.12

SQKM201210025007,还原电势响应的控释系统载体材料及其穿越血脑屏障研究,13万,2012.01-2014.12

 

主编或副主编的著作/译著

张枫,房晨婕,医学化学基础(第2版),中国协和医科大学出版社,2010年

重要奖项

房晨婕,“十二五”期间北京市基金资助项目优秀成果,2017.1

 



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