云顶5555yd 学校首页 | 学院首页 
         
王玉记

 

姓名:王玉记

性别:男

职称:教授

 

招生院所:云顶5555yd

招生类型:博士研究生、硕士研究生

招生专业:药物化学(科学学位)药学(专业学位)

研究方向名称:抗肿瘤、抗血栓药物的设计、合成和药效学研究

电子信箱:ccmuwyj@126.com

个人简介

博士,教授,首都医科大学云顶5555yd副院长。主要从事抗肿瘤、抗血栓药物的设计、合成和药效学研究;其中针对表观遗传学靶点-蛋白精氨酸脱亚胺酶4(PAD4)设计并合成的抑制剂的研究文章( J. Biol. Chem., 2012, 287, 25941)他引用90余次,并且被NIH和宾州州立大学等多家学术网站报道: “work in the Journal of Biological Chemistry suggesting that stopping the action of an enzyme called PAD4 (peptidylarginine deiminase 4) sets off a chain reaction of ‘molecular switches’ in cancer cells. The effect is to switch the internal cell signals from growth to death”。根据这样的设计技术,克服临床上阿司匹林药物的缺点,设计并制备了抗血栓小分子纳米药物。基于以上研究,作为项目负责人获得科技部863青年科学家项目,国家自然科学基金委面上项目,北京长城学者项目、北京市科技新星,北京市高创计划“青年拔尖人才”项目等十余项省部级以上项目资助,已发表SCI期刊论文67余篇(IF="228.2),第一作者或责任作者文章16篇(IF" =70.2),作为封面文章1篇,单篇他引次数最高为110余次;共申请中国发明专利340余项,其中111项授权;申请1项美国专利并获授权;专利转化一项,合同金额300万。

在教学方面,每年承担10余门课程,平均承担600多学时/年的教学工作,能通讲本科生、研究生和留学生等8门课程。一线教学中,“药物的波谱解析”教学坚持本科生“操作大型仪器”,“药学技能实验”教学中坚持“一人一套”实验模式,“药物化学”教学中持续教改,留学生和研究生课贯彻课程思政,这些教学实践提高了本科生和研究生的专业能力以及社会竞争力,获得了学生和同行的好评,于2014年获得霍英东青年教师奖三等奖,2018年获批北京市青年教学名师,2020年“药物的波谱解析”获批国家级一流课程(排名第二);针对药学实验中危险实验,作为第二负责人开发虚拟仿真实验项目60余项,均获得软件著作权,并申请获批2017年国家级虚拟仿真实验项目;主讲的“实验室安全培训”MOOC课程以健康中国和安全生产为目标,在“学堂在线”和“学习强国”在线两个平台上线,其中第一次课播放量已经超过83万次,提高了医药从业者和师生的安全意识、规范了安全操作,扩大了首医影响力;基于以上教育教学工作,共获得获首都医科大学校级教育教学成果一等奖和二等奖各两次(排名前二)。

教育经历

1998年8月至2002年6月    北京大学云顶5555yd  药学         学士

2002年8月至2007年7月      北京大学云顶5555yd  药物化学        博士

工作经历

2007-2009      首都医科大学化学生物学院云顶5555yd,讲师

2009-2010      美国宾州州立大学有机化学系、生物化学及分子生物学系,博士后

2010-2011      首都医科大学化学生物学院云顶5555yd 药化系副主任/讲师

2012-2015      首都医科大学化学生物学院云顶5555yd 药化系主任/副教授

2016至今        首都医科大学化学生物学院云顶5555yd 副院长/教授

重要学术论文:

  1. Yu Lu, Di Zhu, Lin Gui, Yuanming Li, Wenjing Wang, Jiawang Liu and Yuji Wang*. A dual-targeting ruthenium nanodrug that inhibits primary tumor growth and lung metastasis by the PARP/ATM pathway. Journal of Nanobiotechnology, 2021, https://doi.org/10.21203/ rs.3.rs-36952/v1 (doi: 10.21203/rs.3.rs-36952/v1).
  2. Peng Wang, Lin Gui, Yuji Wang,* Sheng Wang*. In vitro evaluation of a pectin-RGDS-OC8H17-paclitaxel nano-particle coated balloon. Applied Nanoscience, 2021, 11:1339–1347
  3. Yu Zhao, Ran Lu, Xin Wang, Xiaochen Huai, Caiyun Wang, Yuji Wang*, Su Chen*. Visible light-induced antibacterial and osteogenic cell proliferation properties of hydrogenated TiO2 nanotubes/Ti foil composite. Nanotechnology, 2021, 32:195101.
  4. Songlin Song, Lin Gui, Qiqi Feng, Ayijiang Taledaohan, Yuanming Li, Wei Wang, Yanming Wang and Yuji Wang*.TAT- modified gold nanoparticles enhance the anti-tumor activity of PAD4 inhibitors. International Journal of Nanomedicine. 2020:15 6659-6671.
  5. Xueyuan Chen, Yi Zheng, Songlin Song,Ying Liu, Yi Wang,Yong Huang,Xiaoyi Zhang, Meng Zhang, Ming Zhao, Yuji Wang*, Li Li*.Design and Synthesis of Biotinylated Bivalent Carboline Derivatives as Potent Antitumor Agents. J. Org. Chem. 2020, 85, 18, 1161811625
  6. Yuji Wang, Xinyi Xu, Ce Song, Jianhui Wu, Xi Hu, Haimei Zhu, Xiaoyi Zhang, Yaonan Wang, Lin Gui, Ming Zhao, Shiqi Peng. ATIQCTPC targeting MMP-9: A key step to slowing primary tumor growth and inhibiting metastasis of Lewis lung carcinoma in vivo. Oncotarget, 2017, 2017, 8: 63881-63889.
  7. Yuji Wang, Jingcheng Tang, Haimei Zhu, Xueyun Jiang, Jiawang Liu, Wenyun Xu, Haiping Ma, Qiqi Feng, Jianhui Wu, Ming Zhao, Shiqi Peng. Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis. International Journal of Nanomedicine, 2015, 10:6905-6918.
  8. Guifeng Kang, Yuji Wang (Co-first author), Jiawang Liu, Jianhui Wu, Ming Zhao, Guochun Li, Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Nathan Mair, Shiqi Peng. Development of three-component conjugates: To get nano-globes with porous surface, high in vivo anti-osteoporosis activity and minimal side effects. Journal of Materials Chemistry, 2012, 22:21740-21748.
  9. Yuji Wang, Jianhui Wu, Guifeng Kang, Ming Zhao, Lin Gui, Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Shiqi Peng. Novel nano-materials, RGD-tetrapeptide-modified 17b-amino-11a-hydroxyandrost-1,4- diene-3-one: synthesis, self-assembly based nano-images and in vivo anti-osteoporosis evaluation. Journal of Materials Chemistry, 2012, 22:4652-4659.
  10. Yuji Wang, Pingxin Li, Shu Wang, Jing Hu, Xiangyun Amy Chen, Jianhui Wu, Megan Fisher, Kira Oshaben, Na Zhao, Ying Gu, Dong Wang, Gong Chen, Yanming Wang. Anticancer PAD inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex activity. Journal of Biological Chemistry, 2012, 287:25941-25953.
  11. Huiliang Zhang, Yuji Wang (Co-first author), Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Lin Gui, Meiqing Zheng, Li Li, Jiawang Liu, Shiqi Peng. Synthesis and In Vivo Lead Detoxification Evaluation of Poly-α,β-DL-aspartyl-L-methionine. Chemical Research in Toxicology, 2012, 25:471-477.
  12. Yuji Wang, Kang Guifeng, Liu Jiawang, Zhao Ming, Wu Jianhui, Zhang Xiaoyi, Li Ye, Zhong Xiaobo, Yang Yifan and Peng Shiqi. Novel potassium N-[(2S,3R,4R,5R)-2,3,4,5,6-Pentahydroxylhex-1-yl]-L-amino acid dichloro- platinates (II) with high anti-tumor activity and low side reaction. Metallomics, 2012, 4:441-447.
  13. Yuji Wang, Xueyun Jiang, Jiawang Liu, Ming Zhao, Guifeng Kang, Jianhui Wu, Li Peng, Shiqi Peng. HPLC-MS aided PC12 cell systems: to quantitatively monitor the conversion of nitronyl nitroxide in biological systems with and without NO. Molecular BioSystems, 2011, 7:1678-1683.
  14. Yuji Wang, Guifeng Kang, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Yifan Yang, Jiawang Liu, Shiqi Peng. A new platinum-complex showing easy preparation, promising anti-tumor activity, and better efficacy and distribution properties than oxaliplatin. Molecular BioSystems, 2011, 7:3245-3252.
  15. Yuji Wang, Lei Wei, Ming Zhao, Shenghui Mei, Meiqing Zheng, Yifan Yang, Hong Wang, Gong Chen, Shiqi Peng. Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice. Metallomics, 2011, 3:1212-1217.
  16. Yuji Wang, Lanrong Bi, Baoguang Hou, Yu Chen, Ming Zhao, Chao Wang, Wei Wang, Jingfang Ju, Shiqi Peng. Design and synthesis of pentahydroxylhexylamino acids and their effect on lead decorporation. Chemical Research in Toxicology, 2007, 20:609-615.
  17. Haimei Zhu, Yuji Wang, Ce Song, et al. Docking of THPDTPI: to explore P-selectin as a common target of anti-tumor, anti-thrombotic and anti-inflammatory agent. Oncotarget, 2018, 9:268-281.
  18. Taiping Gan, Yuji Wang, Ming Zhao, Jianhui Wu, Jian Yang, Shiqi Peng.5-(Bis(3-(2-hydroxyethyl)- 1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHI MHA ): showing a strategy of designing drug to block lung metastasis of tumors.Drug Design, Development and Therapy 2016, 10: 711-721.
  19. Wu J , Zhu H , Zhao M ,Wang Yuji, Yang Guodong, Wang Yaonan, Zhaoshuirui, Gui Lin, Peng shiqi. IQCA-TASS: a nano-scaled P-selectin inhibitor capable of targeting thrombus and releasing IQCA/TARGD(S)S in vivo[J]. Journal of Materials Chemistry B, 2016, 5(5):917-927.
  20. Xi Hu, Ming Zhao, Yuji Wang, Yaonan Wang, Shurui Zhao, Jianhui Wu, Xiangmin Li and Shiqi Peng.Tetrahydro-b-carboline-3-carboxyl-thymopentin: a nano-conjugate for releasing pharmacophores to treat tumor and complications.J. Mater. Chem. B, 2016:4, 1384-1397.
  21. Haimei Zhu, Yuanbo Song, Yuji Wang, Ming Zhao, Yi Ren, Yaonan Wang, Shurui Zhao, Jianhui Wu and Shiqi Peng.Design, synthesis and evaluation of a novel π–π stacking nano-intercalator as an anti-tumor agent. Med. Chem. Commun., 2016, 7, 247-257.
  22. Minna Li, Yuji Wang, Yutong Yang, Yeqing Gao, Ming Zhao, Meiqing Zheng, Shiqi PengOximated ruthenium tris-bipyridyl complex: synthesis and luminescent response specifically for ClO− in water containing multiple ions. Dalton Trans., 2015, 44: 14071-14076.
  23. Jianhui Wu , Haimei Z , Guodong Y , He JianhongWang YujiZhao ShuruiZhang XiaoyiGui Lin, Zhao Ming, Pengshiqi. Design and synthesis of nanoscaled IQCA-TAVV as a delivery system capable of antiplatelet activation, targeting arterial thrombus and releasing IQCA. International Journal of Nanomedicine, 2018, 13:1139-1158.
  24. Feng Wang, Shan Li, Yuji Wang, Haimei Zhu, Xiaoyi Zhang, Ming Zhao, Jianhui Wu, Shiqi Penga, Enantiomeric diketopiperazines: Getting insight of the impact of the configuration to the conformation, nanoimage, u-PA inhibition and anti-metastatic activity. MedChemComm 2015, 6: 956-962.
  25. Wang Xiaozhen, Wang Yuji, Wu Jianhui , et al. Docking based design of diastereoisomeric MTCA as GPIIb/IIIa receptor inhibitor[J]. Bioorganic & Medicinal Chemistry Letters, 2017:5114-5118.
  26. Fei Gao, Haiqing Liu, Li Li, Jianpeng Guo, Yuji Wang, Ming Zhao, Shiqi Peng. Design, synthesis, and testing of an isoquinoline-3-carboxylic-based novel anti-tumor lead Bioorganic & Medicinal Chemistry Letters, 2015, 25: 4434-4436.
  27. Hualong Yu, Shenghui Mei, Li Zhao, Ming Zhao, Yuji Wang, Haimei Zhu, Yaonan Wang, Jianhui Wu, Chunying Cui, Wenyun Xu, Shiqi Peng, RGD-peptides modifying dexamethasone: To enhance the efficacy of anti-inflammation and limit the risk of osteoporosis. Med Chem Comm 2015, 6: 1345-1351.
  28. Shan Li, Yuji Wang, Feng Wang, Yaonan Wang, Xiaoyi Zhang, Ming Zhao, Qiqi Feng, Jianhui Wu, Shurui Zhao, Wei Wu, Shiqi Peng, Small molecule PZL318: Forming fluorescent nanoparticles capable of tracing their interactions with cancer cells and activated platelets, slowing tumor growth and inhibiting thrombosis. Int J Nanomed, 2015, 10:5273-5292.
  29. Shan Li, Yuji Wang, Ming Zhao, Jianhui Wu, Shiqi Peng. BPIC: A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals. Bioorg Med Chem Lett. 2015, 25(5):1146-1150
  30. Wenhua Zhao, Yuji Wang, Weijia Hao, H Yang, Song X, Ming Zhao, Shiqi Peng. Preparative isolation and purification of urolithins from the intestinal metabolites of pomegranate ellagitannins by high-speed counter-current chromatography.J Chromatogr B Analyt Technol Biomed Life Sci. 2015,990:111-117.
  31. Jianhui Wu, Yuji Wang, Yaonan Wang, Ming Zhao, Xiaoyi Zhang, Lin Gui, Shurui Zhao, Haimei Zhu, Jinghua Zhao, Shiqi Peng. Cu2+-RG DFRG DS: exploring the mechanism and high efficacy of the nanoparticle in antithrombotic therapy. International Journal of Nanomedicine 2015, 10: 2925-2938.
  32. Xueyun Jiang, Yuji Wang, Haimei Zhu, Yaonan Wang, Ming Zhao, Shurui Zhao, Jianhui Wu, Shan Li, Shiqi Peng. Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy. Drug Design, Development and Therapy 2015, 9: 2329-2342.
  33. Shuangling Chen, Yuji Wang, Shan Li, Yaonan Wang, Ming Zhao, Haimei Zhu, Jianhui Wu, Shiqi Peng. Poly-α,β-aspartyl-Arg-Gly-Asp-Phe: a novel polymeric nanomedicine. Med. Chem. Commun., 2015, 6:182-186.
  34. Wenhua Zhao, Yuji Wang, Weijia Hao, Ming Zhao, Shiqi Peng.In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-β-D-glucose plays a vital role in anti-tumour activity. Biochem Biophys Res Commun. 2014, 445:346-351.
  35. Fengxiang Du, Xiaoyi Zhang, Shan Li, Yaonan Wang, Meiqing Zheng, Yuji Wang, Shurui Zhao, Jianhui Wu, Lin Gui, Ming Zhao and Shiqi Peng. Mechanism of forming trimer, self-assembling nano-particle and inhibiting tumor growth of small molecule CIPPCT. Med. Chem. Commun., 2014,5: 1634-1643.
  36. Haimei Zhu, Yuji Wang, Yaonan Wang, Shurui Zhao, Ming Zhao, Lin Gui, Wenyun Xu, Xiangyun Amy Chen, Yanming Wang, Shiqi Peng.  Folded Conformation, Cyclic Pentamer, Nano-Structure and PAD4 Binding Mode of YW3-56. The Journal of Physical Chemistry C, 2013, 117:10070-10078.
  37. Haimei Zhu, Yuji Wang, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Guodong Yang, Shiqi Peng. Energy minimized crystal structures of P-selectins based on molecular dynamics simulation: leading to two average structures capable of designing anti-thrombotic agents. Med. Chem. Commun., 2013, 4:1066-1072.
  38. Jiawang Liu, Yuji Wang, Yifan Yang, Xueyun Jiang, Ming Zhao, Wenjing Wang, Guofeng Wu, Jianhui Wu, Meiqing Zheng, Shiqi Peng. Pyrolo[1,2:4,5]-1,4-dioxopyrazino [1,2:1,6]pyrido[3,4-b]indoles: A Group of Urokinase Inhibitors, their Synthesis,and Stereochemistry-Dependent Activity. ChemMedChem, 2011, 6: 2312-2322.
  39. Yanxia Xu, Yuji Wang, Ling Wang, Ming Zhao, Xiaoyi Zhang, Xiaomin Hu, Baoguang Hou, Li Peng, Meiqing Zheng, Jianhui Wu, Shiqi Peng. Lead Detoxification Activities of a Class of Novel DMSA-AminoAcid Conjugates. Chemical Research in Toxicology, 2011, 24: 979-984.
  40. Yanxia Xu, Yuji Wang, Ming Zhao, Baoguang Hou, Li Peng, Meiqing Zheng, Jianhui Wu, Shiqi Peng. Lead detoxification activities and ADMET hepatotoxicities of a class of novel 5-(1-carbonyl-L-amino-acid)-2,2-dimethyl-[1,3]dithiolane-4-carboxylic acids. Bioorganic Medicinal Chemistry Letters, 2011, 21: 1754-1757.   
  41. Yiqing Feng, Yuji Wang, Bradley Landgraf, Shi Liu, Gong Chen. Facile Benzo-Ring Construction via Palladium-Catalyzed Functionalization of Unactivated sp(3) C-H Bonds under Mild Reaction Conditions. Organic Letter, 2010, 12: 3414-3417.
  42. Ming Zhao, Yuji Wang, Caixia Huo, Jiawang Liu, Chunyu Li, Xiaoyi Zhang, Li Peng, Shiqi Peng. Lead Detoxification Activity and ADMET Hepatotoxicity of N-(alpha-l-Arabino-furanos-1-yl)-l-cysteine. Chemical Research in Toxicology, 2010, 23: 1282-1285. 
  43. Ming Zhao, Yuji Wang, Caixia Huo, Chunyu Li, Xiaoyi Zhang, Li Peng, Shiqi Peng. Stereoselective synthesis of novel N-(a-L-arabinofuranos-1-yl)-L-amino acids. Tetrahedron: Asymmetry, 2009, 20: 20247-20258.
  44. Shuangling Chen, Zidong Peng, Yuji Wang, et al. Development and activity evaluation of Arg-Gly-Asp-containing antithrombotic conjugate. Journal of Molecular Structure, 2019, 1198.
  45. Lin Gui, Ming Zhao, Yuji Wang, Yinye Wang, Yang Qin, Li Li, Shiqi Peng. Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-α,β-DL-aspartyl-L-arginine. Medicinal Chemistry Communication, 2012, 3: 102-108.
  46. Jingcheng Tang, Ming Zhao, Yuji Wang, Guifeng Kang, Jianhui Wu, Meiqing Zheng, Shiqi Peng. One single HPLC-PDA/(-)ESI-MS/MS analysis to simultaneously determine 30components of the aqueous extract of Rabdosia rubescens. Journal of Chromatography B, 2011, 879: 2783-2793.
  47. Wenjing Wang, Ming Zhao, Yuji Wang, Jiawang Liu, Jianhui Wu, Guifeng Kang, Shiqi Peng. {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl- ethyl]-1H-indol-3-yl} acetic acid methyl ester (MIAM): its anti-cancer efficacy and intercalation mechanism identified via multi-model systems. Molecular BioSystems, 2011, 7: 766-772.
  48. Shaoming Jin, Yaonan Wang, Haimei Zhu, Yuji Wang, Shurui Zhao, Ming Zhao, Jiawang Liu, Jianhui Wu, Wen Gao, Shiqi Peng. Nanosized Aspirin-Arg-Gly-Asp-Val: Delivery of Aspirin to Thrombus by the Target Carrier Arg-Gly-Asp-Val Tetrapeptide. ACS Nano, 2013, 7: 7664-7673.
  49. Li Li, Ming Zhao, Wenhao Li, Yuji Wang, Chunna Liu, Zhuge Zhang, Songchun Su,Shiqi Peng. pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy. Nanomedicine:NBM, 2012, DOI:10.1016/j.nano.2011.12.008
  50. Li Li, Ming Zhao, Wenhao Li, Yuji Wang, Zhuge Zhang, Ran An, Shiqi Peng. Self-complexation and complexation-controlled target cancer therapy. Medicinal Chemistry Communication, 2012, 3: 1059-1061.
  51. Li Li, Jianhui Wu, Ming Zhao, Yuji Wang, Huiliang Zhang, Xiaoyi Zhang, Lin Gui, Jiawang Liu, Nathan Mair, Shiqi Peng. Poly-α,β-dl-Aspartyl-l-Cysteine: A Novel Nanomaterial Having a Porous Structure, Special Complexation Capability for Pb(II), and Selectivity of Removing Pb(II). Chemical Research in Toxicology,2012, 25: 1948-1954
  52. Chunyu Li, Xiaoyi Zhang, Ming Zhao, Yuji Wang, Jianhui Wu, Jiawang Liu, Meiqing Zheng, Shiqi Peng. A class of novel N-(1-methyl-b-carboline-3-carbonyl)-N’ -(aminoacid-acyl)- hydrazines: Aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. European Bioorganic Medicinal Chemistry, 2011, 46: 5598-5608.
  53. Lu R , Wang C , Wang X ,Wang Yuji, Chen Shu. Effects of hydrogenated TiO2 nanotube arrays on protein adsorption and compatibility with osteoblast-like cells[J]. International Journal of Nanomedicine, 2018, 13:2037-2049.
  54. Jianhui Wu, Lei Wei, Ming Zhao, Yuji Wang, Guifeng Kang, Shiqi Peng. N-[2(3-Carboxyl-9-benzyl-carboline-1-yl)ethyl-1-yl]-amino acids: correlation of spectral property with in vivo anti-tumor activity. Medicinal Chemistry Research, 2010, DOI:10.1007/s00044-010-9504-1
  55. Li Li, Guohui Cui, Ming Zhao, Yuji Wang, Hong Wang, Wei Li, Shiqi Peng . Assembly of beta-cyclodextrin with 3S-tetrahydro-beta-carboline-3-carboxylic acid and self-assembly of 6-(3'S-carboline-3'-carboxylaminoethylamino)-6-deoxy-β-cyclodextrin. Journal of Physical Chemistry B, 2008, 112: 12139-12147.
  56. Kun Yao, Ming Zhao, Xiaoyi Zhang, Yuji Wang, Li Li, Meiqing Zheng, Shiqi Peng. A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-b-carboline-3-carbonyl]- N-(amino-acid-acyl) hydrazine: Discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. European Journal of Medicinal Chemistry, 2011, 46: 3237-3249.
  57. Guodong Yang, Haimei Zhu, Ming Zhao, Jianhui Wu, Yuji Wang, Yanju Wang, Meiqing Zheng, Min Chen, Jiawang Liu, Shiqi Peng. The application of tetrahydroisoquinoline-3-carbonyl-TARGD(F) F as an anti-thrombotic agent having dual mechanisms of action. Molecular BioSystems, 2012, 8: 2672-2679.
  58. Shenghui Mei, Jiawang Liu, Ming Zhao, Wenjing  Wang, Yuji Wang, Guofeng Wu, Meiqing Zheng, Shiqi Peng. From Cerius2 based stereoview to mouse and enzyme: the model systems for discovery of novel urokinase inhibitors. Molecular BioSystems, 2011, 7: 2664-2669.
  59. Jianhui Wu , Chunyu Li, Ming Zhao, Wenjing Wang, Yuji Wang, Shiqi Peng. A class of novel carboline intercalators: Their synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and 3D QSAR analysis. Bioorganic & Medicinal Chemistry, 2010, 18: 6220-6229.
  60. Hong Wang, Le Peng, Ming Zhao, Jiawang Liu, Xiaoyi Zhang, Yuji Wang, Jianhui Wu, Li Li, Shiqi Peng. 2-Substituted (S)-2-(3,3-dimethyl-1-oxo- 10,10a-dihydroimidazo[1,5-b] isoquinolin-2(1H,3H,5H)-yl) acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation. Bioorganic & Medicinal Chemistry, 2011, 19: 871-882.
  61. Xiaoyi Zhang, Yifan Yang, Ming Zhao, Liu Liu, Meiqing Zheng, Yuji Wang, Jianhui Wu, Shiqi Peng. A class of Trp-Trp-AA-OBzl: Synthesis, in vitro anti-proliferation/in vivo anti-tumor evaluation, intercalation-mechanism investigation and 3D QSAR analysis, European Bioorganic Medicinal Chemistry, 2011, 46: 3410-3419.
  62. Meiqing Zheng, Xiaoyi Zhang, Ming Zhao, Heng Wei Chang, Wei Wang, Yuji Wang, Shiqi Peng. (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis. Bioorganic Medicinal Chemistry, 2008, 16: 9574-9587.
  63. Jiawang Liu,Shannon Taylor, Patrick Dupart, Corey Arnold, Jayalakshmi Sridhar, Quan Jiang, Yuji Wang, Elena Skripnikova, Ming Zhao, Maryam Foroozesh. Pyranoflavones: A Group of Small-molecule Probes for Exploring the Active Site Cavities of Cytochrome P450 Enzymes 1A1, 1A2, and 1B1. Journal of Medicinal Chemistry, 2013, 56: 4082-4092.
  64. Liu Liu, Lei Wei, Yifan Yang, MingZhao, Xiaoyi Zhang, Meiqing Zheng, Yuji Wang, Shiqi Peng. A class of novel AA-Trp-Trp-OBzl: synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and intercalation mechanism. Medicinal Chemistry Communication, 2011, 2: 126-131.
  65. Meiqing Zheng, Yifan Yang, Xiaoyi Zhang, Ming Zhao, Jianhui Wu, Gong Chen, Li Peng, Yuji Wang, Peng Shiqi. A class of novel N-isoquinoline-3-carbonyl-l-amino acid benzyl esters: Synthesis, anti-tumor evaluation and 3D QSAR analysis. European Bioorganic Medicinal Chemistry, 2011, 46: 1672-1681.
  66. Adharsh P. Ponnapakam, Jiawang Liu, Kaustubh N. Bhinge, Barbara A. Drew, Tony L. Wang, James W. Antoon, Thong T. Nguyen, Patrick S. Dupart, Yuji Wang, Ming Zhao, Yong-Yu Liu, Maryam Foroozesh , Barbara S. Beckmana. 3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells. Bioorganic & Medicinal Chemistry, 2014 , 22: 1412-1420.
  67. Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LJ, Yuji Wang, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M. A Ligand-Based Drug Design, Discovery of 4-Trifluoromethyl-7,8-Pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.J Med Chem. 2015, 58: 6481-6493

承担重要项目

2018-2020年 北京长城学者项目,小分子PAD4抑制剂抗肿瘤药物研究,300万

2015-2018年 科技部863青年科学家项目,小分子抗肿瘤药物纳米制备技术研究,117万

2015年北京市科技转化项目,鸟氨酸试剂盒的开发研究,50万

2015-2018年 北京市高创计划项目,小分子纳米抗肿瘤药物研究,50万

2014-2017年年国家自然科学基金面上项目可对接PAD4活性口袋扰乱肿瘤细胞自噬的精氨酸衍生物的构效关系研究,61万

2013年北京市科技新星项目,新型PAD4抑制剂的合成及抗肿瘤分子机理研究,35万

2009-2011年国家自然科学基金青年项目N-葡萄糖基-L-氨基酸络二氯铂的设计合成与抗肿瘤活性评价,19万

重要奖项

2018年北京市青年教学名师

2015年北京市高创计划“青年拔尖人才”

2014年霍英东青年教师奖三等奖

2013年北京市科技新星

2011年北京市教育先锋号(排名2)

 



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